Clinical Studies

Highest Reported Survival for All Rhythms

Among the large prospective clinical trials that have been published using an automated CPR device, the AutoPulse® Resuscitation System has achieved the highest survival rate. In the CIRC (Circulation Improving Resuscitation Care) trial, the overall survival-to-discharge rate was 10.2%—among the highest ever achieved in an out-of-hospital cardiac arrest (OHCA) trial.1 The PARAMEDIC trial, which used a piston-driven mechanical CPR device, had a 30-day survival rate of just 6.6%.2

Survival from OHCA

At 10.2%, survival in the CIRC trial was among the highest ever achieved in an OHCA trial.1 Survival in the PARAMEDIC trial was just 6.6%.2


Enhanced Circulation with Unmatched Impact on ROSC

Multiple comparative studies have demonstrated improved vital signs because the AutoPulse drives superior blood flow, resulting in coronary perfusion pressure levels 33% higher than those of sternal compressions, positively impacting return of spontaneous circulation (ROSC) and survival. Furthermore, while piston-driven sternal CPR devices have shown no benefit in improving ROSC rates when compared to manual CPR,3 the AutoPulse has increased ROSC rates in numerous studies.4-9

AutoPulse Drives ROSC Rates Up
Multiple trials confirm the AutoPulse is superior to manual CPR when it comes to increasing a patient’s odds of achieving ROSC.

1Wik L, et al. Resuscitation. 2014;85:741–748.
2Perkins GD, et al. The Lancet. 2015:385(9972)947–955.
3Westfall M, et al. Crit Care Med. 2013 Jul;41(7):1782–1789.
4Ong ME, et al. JAMA. 2006; 295:2629–2637.
5Casner M, et al. Prehosp Emerg Care. 2005;9:61–67.
6Steinmetz J, et al. Acta Anaesthesiol Scand. 2008;52:908–913.
7Paradis NA, et al. Circulation. 2009;120:S1457.
8Swanson M, et al. Circulation. 2006;114:II_554.
9Jennings PA, et al. Resuscitation. 2010.09.093;S20.


Additional Clinical References

Halperin HR, et al. Cardiopulmonary resuscitation with a novel chest compression device in a porcine model of cardiac arrest: improved hemodynamics and mechanisms. (abstract) Journal of the American College of Cardiology. 2004;44(11):2214–2220.
Krep H et al. Out-of-hospital cardiopulmonary resuscitation with the AutoPulse system: a prospective observational study with a new load-distributing band chest compression device. Resuscitation. 2007;73:86–95.
Timerman S, et al. Improved hemodynamic performance with a novel chest compression device during treatment of in-hospital cardiac arrest. (abstract) Resuscitation. 2004;61:273–280.