Publications

Key Citations

Below is a list of citations and publication links for information listed on this website.

• Kloner, et al. Update on Cardioprotective Strategies for STEMI: Focus on Supersaturated Oxygen Delivery. J Am Coll Cardiol Basic Trans Science. 2021:1–7.
  https://doi.org/10.1016/j.jacbts.2021.07.011
• Chen, S, David, SW, Khan, ZA, et al. One‐year outcomes of supersaturated oxygen therapy in acute anterior myocardial infarction: The IC‐HOT study. Catheter Cardiovasc Interv. 2020; 1– 7. https://doi.org/10.1002/ccd.29090
• David SW, et al. Evaluation of intracoronary hyperoxemic oxygen therapy in acute anterior myocardial infarction: The IC-HOT study. Catheter Cardiovasc Interv. 2018;1–9.
  https://onlinelibrary.wiley.com/doi/abs/10.1002/ccd.27905
• Stone GW, et al. Effect of supersaturated oxygen delivery on infarct size after percutaneous coronary intervention in acute myocardial infarction. Circ Cardiovasc Interv. Sep 2009. 2; 366-375.
  https://www.ahajournals.org/doi/full/10.1161/CIRCINTERVENTIONS.108.840066?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
• O’Neill WW, et al. Acute Myocardial Infarction With Hyperoxemic Therapy (AMIHOT), A Prospective, Randomized Trial of Intracoronary Hyperoxemic Reperfusion After Percutaneous Coronary Intervention. Jour of Am Coll Cardiol. 2007;50; No.5. 397-405.
  https://www.sciencedirect.com/science/article/pii/S0735109707015525?via%3Dihub
• Warda HM, et al. Effect of intracoronary aqueous oxygen on left ventricular remodeling after anterior wall ST-elevation acute myocardial infarction. Am J Cardiol. 2005;96(1): 22-24.
  https://www.ajconline.org/article/S0002-9149(05)00571-0/fulltext
• Bartorelli AL. Hyperoxemic Perfusion for Treatment of Reperfusion Microvascular Ichemia in Patients with Myocardial Infarction. Am J Cardiovasc Drugs. 2003;3:253-63.
  https://link.springer.com/article/10.2165%2F00129784-200303040-00004
• Spears JR, et al. Aqueous Oxygen Attenuation of Reperfusion Microvascular Ischemia in a Canine Model of Myocardial Infarction. ASAIO Jour. 2003 Nov-Dec;49(6):716-20.
  https://journals.lww.com/asaiojournal/fulltext/2003/11000/Aqueous_Oxygen_Attenuation_of_Reperfusion.20.aspx

Other Relevant Publications

The list below represents other studies, evaluations and publications related to TherOx SSO₂ Technology.

• Spears JR. Reperfusion Microvascular Ischemia After Prolonged Coronary Occlusion: Implications And Treatment With Local Supersaturated Oxygen Delivery. Hypoxia (Auckl). 2019;7:65‐79. Published 2019 Oct 21.
• Katukuri N, et al. “Aqueous Oxygen for Treatment of ST- Segment Elevation Myocardial Infarction”. Urgent Interventional Therapies. Nicholas N. Kipshidze, Jawed Fareed, Robert T. Rosen, George D. Dangas, Patrick W. Serruys. John Wiley & Sons, Oxford, 2015; 502-508.
• Spears JR, et al. Intracoronary aqueous oxygen perfusion, performed 24 hrs after the onset of postinfarction reperfusion, experimentally reduces infarct size and improves left ventricular function. International J Cardiol. 18 November 2008; 113- 371-5.
• Spears JR, et al. Aqueous oxygen near the homogeneous nucleation limit of water: stabilization with submicron capillaries. ASAIO Journal. 2006; 52: 186-191.
• Spears JR, et al. Aqueous Oxygen Attenuation of Reperfusion Microvascular Ischemia in a Canine Model of Myocardial Infarction. ASAIO Journal. 2003; 49: 716-720.
• Spears JR, et al. Aqueous Oxygen Hyperbaric Reperfusion in a Porcine Model of Myocardial Infarction. J Invasive Cardiology. 2002; 14: 160-166.
• Dixon SR, et al. Early recovery of infarct zone function with intracoronary hyperoxemia reperfusion after primary angioplasty for acute myocardial infarction. JACC.2002; 39: 387-92.
• Brereton GJ, Crilly RJ, Spears JR. Nucleation in small capillary tubes. Chemical Physics. 1998; 230: 253-265.
• Spears JR, et al. Aqueous Oxygen: a highly O2-supersaturated infusate for regional correction of hypoxemia and production of hyperoxemia. Circulation. 1997; 96:4385-4391.
• Spears JR. Advances in the Management of Respiratory Failure. Aqueous preparations of oxygen. ASAIO Journal. 1996; 42:196-198.